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Cannabis and cannabinoids preclinical pharmacology

  1. Among pathways involved in the pathogenesis of coronavirus disease 2019 (COVID-19), impaired endothelial cell (EC) function and angiogenesis have been discussed less frequently than others such as cytokine sto...

    Authors: Nazanin Ashtar Nakhaei, Andisheh Najarian, Mohammad Hosein Farzaei and Amir Hossein Norooznezhad
    Citation: Journal of Cannabis Research 2022 4:21
  2. Cannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa, has recently been found to have anticonvulsant properties in the Scn1a+/- mouse model of Dravet syndrome. Poor brain penetration and chemica...

    Authors: Lyndsey L. Anderson, Michael Udoh, Declan Everett-Morgan, Marika Heblinski, Iain S. McGregor, Samuel D. Banister and Jonathon C. Arnold
    Citation: Journal of Cannabis Research 2022 4:2
  3. Acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome whose potential to become one of the most grievous challenges of the healthcare system evidenced by the COVID-19 pandemic. Con...

    Authors: Hesam Khodadadi, Évila Lopes Salles, Eunice Shin, Abbas Jarrahi, Vincenzo Costigliola, Pritesh Kumar, Jack C. Yu, John C. Morgan, David C. Hess, Kumar Vaibhav, Krishnan M. Dhandapani and Babak Baban
    Citation: Journal of Cannabis Research 2021 3:45
  4. Whole-plant cannabis extracts are consumed by the public for medical and non-medical (“recreational”) purposes but are poorly researched compared to pure cannabinoids. There is emerging evidence that cannabis ...

    Authors: Jessica Nixon, Hanan Abramovici, Ashley Cabecinha, Camilo Martinez-Farina, Joseph Hui and Lee Ellis
    Citation: Journal of Cannabis Research 2021 3:44
  5. Lipid profile and redox status play a role in brain (dys)functions. Cannabinoid and melatonergic systems operate in the brain and contribute to brain (patho)physiology, but their roles in the modulation of bra...

    Authors: Halimat Amin Abdulrahim, Isiaka Abdullateef Alagbonsi, Oluwasola Amuda, Noah Adavize Omeiza, Abdul-Rahuf Aderemi Feyitimi and Luqman Aribidesi Olayaki
    Citation: Journal of Cannabis Research 2021 3:38
  6. Cannabidiol (CBD) has been reported to have anti-diabetic effects in pre-clinical and clinical studies but its inhibitory effects on α-glucosidase, a carbohydrate hydrolyzing enzyme, remain unknown. Herein, we ev...

    Authors: Hang Ma, Huifang Li, Chang Liu and Navindra P. Seeram
    Citation: Journal of Cannabis Research 2021 3:20
  7. There is a worldwide interest in the use of Cannabis sativa for biomedicine purposes. Cannabis has ethnomedicinal usage as a natural medicine in Bangladesh and cultivated during the British Empire period for reve...

    Authors: Shahriar S. M. Shakil, Matt Gowan, Kerry Hughes, Md. Nur Kabidul Azam and Md. Nasir Ahmed
    Citation: Journal of Cannabis Research 2021 3:8
  8. Multiple therapeutic properties have been attributed to Cannabis sativa. However, further research is required to unveil the medicinal potential of Cannabis and the relationship between biological activity and ch...

    Authors: Bruno Musetti, Helena González-Ramos, Mercedes González, Edward M. Bahnson, Javier Varela and Leonor Thomson
    Citation: Journal of Cannabis Research 2020 2:37
  9. Cannabis contains Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) as the primary constituents responsible for pharmacological activity. However, there are numerous additional chemically-related structures ...

    Authors: Alykhan Devsi, Brett Kiyota, Theophile Ouellette, Andrew P. Hegle, Ricardo E. Rivera-Acevedo, Jasper Wong, Ying Dong, Michael K. Pugsley and Timothy Fung
    Citation: Journal of Cannabis Research 2020 2:17
  10. Substantial advancements were achieved in the management of postoperative pain, however the need for further improvement remains. This study explores the pharmacokinetics and safety of the CannaHaler, a metere...

    Authors: Offir Ben-Ishay, Ortal Bar-On and Yoram Kluger
    Citation: Journal of Cannabis Research 2020 2:15
  11. Chronic obstructive pulmonary disease (COPD) is commonly associated with both a pro-inflammatory and a T-helper 1 (Th1) immune response. It was hypothesized that cannabis oil extract can alleviate COPD symptom...

    Authors: Stephen W. Mamber, Volkan Gurel, Jeremy Lins, Fred Ferri, Sarah Beseme and John McMichael
    Citation: Journal of Cannabis Research 2020 2:5