Articles

Frequency of cannabis use and alcohol-associated adverse effects in a representative sample of U.S. adolescents and youth (2002–2014) a cross-sectional study

While the link between frequent cannabis use and alcohol use disorders is well documented, it is not clear whether alcohol drinkers who use cannabis less frequently are also vulnerable to alcohol use disorders...

Authors: Majed M. Ramadan, Jim E. Banta, Khaled Bahjri and Susanne B. Montgomery

Cannabis sativa extracts protect LDL from Cu²⁺-mediated oxidation

Multiple therapeutic properties have been attributed to Cannabis sativa. However, further research is required to unveil the medicinal potential of Cannabis and the relationship between biological activity and ch...

Authors: Bruno Musetti, Helena González-Ramos, Mercedes González, Edward M. Bahnson, Javier Varela and Leonor Thomson

Motivations and expectations for using cannabis products to treat pain in humans and dogs: a mixed methods study

Social media and academic literature suggest that more people are using cannabis to treat their own or their dog’s chronic pain. This study identifies the reasons people use cannabis products to treat their ow...

Authors: Jean E. Wallace, Lori R. Kogan, Eloise C. J. Carr and Peter W. Hellyer

Methods for quantification of cannabinoids: a narrative review

Around 144 cannabinoids have been identified in cannabis plant, among them tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most prominent ones. Because of the legal restrictions on cannabis in many co...

Authors: Masoumeh Pourseyed Lazarjani, Stephanie Torres, Thom Hooker, Chris Fowlie, Owen Young and Ali Seyfoddin

Chronic cannabis consumption and physical exercise performance in healthy adults: a systematic review

The effects of chronic cannabis consumption on physiological parameters of athletic performance are investigated to determine whether chronic cannabis consumption negatively affects athletic performance; impro...

Authors: Andrew Kramer, Justin Sinclair, Lara Sharpe and Jerome Sarris

Perspectives on formation of medical cannabis market in Ukraine based on holistic approach

Nowadays, medical cannabis still remains inaccesible for patients in the former Union of Soviet Socialist Republics (USSR). Even registered medicinal products based on herbal or synthetic cannabinoids, like Sa...

Authors: Nataliia Aliekperova, Кostyantyn Kosyachenko and Oleksandr Kaniura

Medical cannabis use in the United States: a retrospective database study

Growing interest in the medicinal properties of cannabis has led to an increase in its use to treat medical conditions, and the establishment of state-specific medical cannabis programs. Despite medical cannab...

Authors: V. Kishan Mahabir, Jamil J. Merchant, Christopher Smith and Alisha Garibaldi

Public interest in Cannabis during election season: a Google Trends analysis

Given that 72% of internet users seek out health information using an internet search engine (Google being the most popular); we sought to investigate the public internet search interest in cannabis as a healt...

Authors: Trevor Torgerson, Will Roberts, Drew Lester, Jam Khojasteh and Matt Vassar

Cannabis as entheogen: survey and interview data on the spiritual use of cannabis

While cannabis has a long history of spiritual use, its normalization in Western societies during the last decades has led to more recreational use. This study aimed to explore the characteristics of spiritual...

Authors: Petter Grahl Johnstad

A content analysis of internet information sources on medical cannabis

Medical cannabis users report that their knowledge regarding cannabis is predominantly from their own personal experiences and the Internet.

Authors: Daniel J. Kruger, Ilana M. Moffet, Liliah C. Seluk and Lara A. Zammit

Acute effects of naturalistic THC vs. CBD use on recognition memory: a preliminary study

The ratio of ∆9-tetrahydrocannabinol (THC) to cannabidiol (CBD) varies widely across cannabis strains. CBD has opposite effects to THC on a variety of cognitive functions, including acute THC-induced memory im...

Authors: Tim Curran, Hélène Devillez, Sophie L. YorkWilliams and L. Cinnamon Bidwell

The preservation and augmentation of volatile terpenes in cannabis inflorescence

Terpenes contribute to the pharmacology, efficacy, aroma, and flavor of cannabis inflorescence, improving the experience for medical and recreational users. Terpenes are inherently volatile, resulting in the l...

Authors: Justin Bueno, Emily Leuer, Michael Kearney Jr, Edward H. Green and Eric A. Greenbaum

A single nucleotide polymorphism assay sheds light on the extent and distribution of genetic diversity, population structure and functional basis of key traits in cultivated north American cannabis

The taxonomic classification of Cannabis genus has been delineated through three main types: sativa (tall and less branched plant with long and narrow leaves), indica (short and highly branched plant with broader...

Authors: Philippe Henry, Surender Khatodia, Karan Kapoor, Britni Gonzales, Alexis Middleton, Kevin Hong, Aaron Hilyard, Steve Johnson, Davis Allen, Zachary Chester, Dan Jin, José Carlos Rodriguez Jule, Iain Wilson, Manu Gangola, Jason Broome, Deron Caplan…

Minnesota wild hemp: a crucial botanical source in early cannabinoid discovery

Renewed and sustained Cannabis chemistry exploration was initiated by Roger Adams at the University of Illinois Chemistry Department with cooperation from the Treasury Department Narcotics Laboratory in the early...

Authors: Crist N. Filer

Pharmacogenetic-guided cannabis usage in the community pharmacy: evaluation of a pilot program

Pharmacists possess a skillset suited to provide evidence-based guidance to current and potential users of cannabis. Clinical pharmacogenomics research has made significant progress in defining which genetic v...

Authors: John Papastergiou, Wilson Li, Carly Sterling and Bart van den Bemt

The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection

Coronavirus disease 2019 (COVID-19) is spreading fast all around the world with more than fourteen millions of detected infected cases and more than 600.000 deaths by 20th July 2020. While scientist are workin...

Authors: Alberto Sainz-Cort and Joost H. Heeroma

Government-mandated warnings on cannabis legally sold for recreational use

Frequent cannabis use can pose risks to health and safety. Multiple governments have legalized the sale of cannabis for recreational use and mandated health and safety warnings for recreational cannabis packag...

Authors: John M. Malouff and Ben P. Schutte-Malouff

Relationship among subjective responses, flavor, and chemical composition across more than 800 commercial cannabis varieties

Widespread commercialization of cannabis has led to the introduction of brand names based on users’ subjective experience of psychological effects and flavors, but this process has occurred in the absence of a...

Authors: Alethia de la Fuente, Federico Zamberlan, Andrés Sánchez Ferrán, Facundo Carrillo, Enzo Tagliazucchi and Carla Pallavicini

Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples

Dental plaque is a global health problem affecting people of various age groups. Cannabinoids are gaining enormous research attention due to its beneficial properties for various applications. A preliminary ob...

Authors: Kumar Vasudevan and Veronica Stahl

Cannabinoids for fibromyalgia pain: a critical review of recent studies (2015–2019)

Fibromyalgia is a chronic health condition characterized by widespread, severe musculoskeletal pain that affects an estimated 5–7% of the global population. Due to the highly comorbid nature of fibromyalgia, p...

Authors: Erinn C. Cameron and Samantha L. Hemingway

Attitudes about cannabis mediate the relationship between cannabis knowledge and use in active adult athletes

Little is known about how cannabis knowledge and attitudes impact cannabis use behavior.

Authors: Joanna S. Zeiger, William S. Silvers, Edward M. Fleegler and Robert S. Zeiger

A pharmacological characterization of Cannabis sativa chemovar extracts

Cannabis contains Δ⁹-tetrahydrocannabinol (Δ⁹-THC) and cannabidiol (CBD) as the primary constituents responsible for pharmacological activity. However, there are numerous additional chemically-related structures ...

Authors: Alykhan Devsi, Brett Kiyota, Theophile Ouellette, Andrew P. Hegle, Ricardo E. Rivera-Acevedo, Jasper Wong, Ying Dong, Michael K. Pugsley and Timothy Fung

Ohio physician attitudes toward medical Cannabis and Ohio’s medical marijuana program

Ohio’s medical cannabis program is one of three states that require physicians to become certified to recommend medical cannabis to their patients. The current study examines the attitudes of Ohio physicians t...

Authors: Emilia Lombardi, Joshua Gunter and Erin Tanner

Smokeless consumption of medical cannabis pharmacokinetics, safety and feasibility of the CannaHALER© a phase 1a study

Substantial advancements were achieved in the management of postoperative pain, however the need for further improvement remains. This study explores the pharmacokinetics and safety of the CannaHaler, a metere...

Authors: Offir Ben-Ishay, Ortal Bar-On and Yoram Kluger

Patterns and correlates of cannabis use by cumulative lifetime violence severity as target and/or perpetrator in a community sample of eastern Canadian men

Recent Canadian legalization of cannabis for non-medical use underscores the need to understand patterns and correlates of cannabis use among men who may be more likely than women to become problematic cannabi...

Authors: Sue O’Donnell, Kelly Scott-Storey, Judith Wuest, Jeannie Malcolm, Petrea Taylor and Charlene D. Vincent

The relationship of cannabis decriminalization in Colorado and cannabis use in individuals with alcohol use disorders

Over the past decade, cannabis use has become increasingly popular in states that include Colorado. During this time, alcohol use disorders (AUDs) and alcohol-related medical conditions have also been consiste...

Authors: Jeremy T. Hua, Majid Afshar, Brendan J. Clark, Elizabeth J. Kovacs and Ellen L. Burnham

Effects of cold plasma, gamma and e-beam irradiations on reduction of fungal colony forming unit levels in medical cannabis inflorescences

The use of medical cannabis (MC) in the medical field has been expanding over the last decade, as more therapeutic beneficial properties of MC are discovered, ranging from general analgesics to anti-inflammato...

Authors: Shachar Jerushalmi, Marcel Maymon, Aviv Dombrovsky and Stanley Freeman

The distribution of Ohio’s Certificates to Recommend: who will “prescribe” medical marijuana?

Under Ohio Medical Marijuana Control Program rules, Ohio physicians that recommend medical marijuana (MMJ) to patients must possess a Certificate to Recommend (CTR) from the State Medical Board. Although a pre...

Authors: Frederic Stuart Leeds, Ryan K. Levinthal, Morgan T. Alexander and Timothy N. Crawford

Recurrent priapism in the setting of cannabis use

Priapism (persistent and painful erection of the penis) is a notable urological emergency, with over 90% of those remaining erect for 24 h losing sexual function. Drug-induced priapism is common in the adult p...

Authors: Sebastian Montgomery, Kristal Sirju, Joseph Bear, Latha Ganti and John Shivdat

Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes

Δ9-Tetrahydrocannabivarin (THCV) is a cannabis-derived compound with unique properties that set it apart from the more common cannabinoids, such as Δ9-tetrahydrocannabinol (THC). The main advantage of THCV ove...

Authors: Amos Abioye, Oladapo Ayodele, Aleksandra Marinkovic, Risha Patidar, Adeola Akinwekomi and Adekunle Sanyaolu

Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)

Chronic obstructive pulmonary disease (COPD) is commonly associated with both a pro-inflammatory and a T-helper 1 (Th1) immune response. It was hypothesized that cannabis oil extract can alleviate COPD symptom...

Authors: Stephen W. Mamber, Volkan Gurel, Jeremy Lins, Fred Ferri, Sarah Beseme and John McMichael

The use of cannabis for Hyperemesis Gravidarum (HG)

Hyperemesis Gravidarum (HG) responds only partially to standard antiemetic medications. Cannabis has been known to possess antiemetic effects and there are several medicinal cannabinoids used as anti -emetics ...

Authors: Gideon Koren and Rana Cohen

Overbaked: assessing and predicting acute adverse reactions to Cannabis

Trends toward legalizing cannabis may increase experimentation with the drug among less experienced users with limited knowledge of possible adverse reactions. This study explores the prevalence, frequency, an...

Authors: Emily M. LaFrance, Amanda Stueber, Nicholas C. Glodosky, Dakota Mauzay and Carrie Cuttler

The therapeutic role of Cannabidiol in mental health: a systematic review

The therapeutic application of cannabidiol (CBD) is gaining interest due to expanding evidence for its use.

Authors: Rabia Khan, Sadiq Naveed, Nadeem Mian, Ania Fida, Muhammad Abdur Raafey and Kapil Kiran Aedma

Analysis of the cannabinoid content of strains available in the New Jersey Medicinal Marijuana Program

The six licensed operators in the New Jersey Medicinal Marijuana Program submit their strains of cannabis flower to a single laboratory, administered by the state’s Department of Health, for testing. The resul...

Authors: Thomas A. Coogan

Correction to: A smartphone app intervention for adult cannabis users wanting to quit or reduce their use: a pilot evaluation

Following publication of the original article (Albertella et al. 2019), the authors have flagged an error concerning the reference to the ‘follow-up Mann-Whitney U test’ in the Results section of the article.

Authors: Lucy Albertella, Lisa Gibson, Sally Rooke, Melissa M. Norberg and Jan Copeland

A smartphone app intervention for adult cannabis users wanting to quit or reduce their use: a pilot evaluation

Smartphone applications (apps) offer a promising alternative to face-to-face treatment due to their ease of access and convenience. However, there is a lack of evidence-based apps for cannabis users wishing to...

Authors: Lucy Albertella, Lisa Gibson, Sally Rooke, Melissa M. Norberg and Jan Copeland

Distribution of cannabinoid synthase genes in non-Cannabis organisms

The discovery of phytocannabinoid synthesizing enzymes, tetrahydrocannabinolic acid synthase (THCAs) and cannabidiolic acid synthase (CBDAs) was a breakthrough in Cannabis research. However, their evolutionary...

Authors: Niranjan Aryal, Debbie Figueroa Orellana and Jamal Bouie

Age related differences in cannabis use and subjective effects in a large population-based survey of adult athletes

There is a paucity of information regarding cannabis use behaviors in adult community-based athletes as most research in athletes has focused on misuse of cannabis in elite, adolescent, university-based athlet...

Authors: Joanna S. Zeiger, William S. Silvers, Edward M. Fleegler and Robert S. Zeiger

Total and differential white blood cell count in cannabis users: results from the cross-sectional National Health and Nutrition Examination Survey, 2005–2016

Elevated white blood cell (WBC) count in tobacco cigarette smokers compared to non-smokers has been well documented, but little is known on circulating WBC counts and cannabis use.

Authors: Omayma Alshaarawy

Cannabis use patterns at the dawn of US cannabis reform

In the United States (US), three in 10 cannabis users develop cannabis use disorder (CUD). Usage patterns in line with CUD may be associated with socio-economic disadvantage, and other negative effects. Thus, ...

Authors: Navin Kumar, Cheneal Puljević, Jason Ferris, Adam Winstock and Monica J. Barratt

Molecular neuroscience at its “high”: bibliometric analysis of the most cited papers on endocannabinoid system, cannabis and cannabinoids

Cannabis, cannabinoids and endocannabinoids are heavily investigated topics with many articles published every year. We aimed to identify the 100 most cited manuscripts among the vast literature and analyze th...

Authors: Andy Wai Kan Yeung, Nikolay T. Tzvetkov, Nicolas Arkells, Luigi Milella, Adrian M. Stankiewicz, Łukasz Huminiecki, Olaf K. Horbanczuk and Atanas G. Atanasov

Genetic tools weed out misconceptions of strain reliability in Cannabis sativa: implications for a budding industry

Unlike other plants, Cannabis sativa is excluded from regulation by the United States Department of Agriculture (USDA). Distinctive Cannabis varieties are ostracized from registration and therefore nearly impossi...

Authors: Anna L. Schwabe and Mitchell E. McGlaughlin

High school student cannabis use and perceptions towards cannabis in southcentral Colorado – comparing communities that permit recreational dispensaries and communities that do not

Currently, with the legalization of cannabis and the opening of recreational dispensaries in states across the country, the question of whether or not proximity to recreational cannabis dispensaries affects hi...

Authors: Tim Peters and Carol Foust

Journal of Cannabis Research: a new international, multi-disciplinary, open access journal

Authors: David A. Gorelick