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Table 1 Dosing regimen

From: Oral Cannabis consumption and intraperitoneal THC:CBD dosing results in changes in brain and plasma neurochemicals and endocannabinoids in mice

Matrix

Delivery

Dosing Group

CBD mg/kg/day

Δ9-THC mg/kg/day

Purified THC:CBD

i.p

Control

0

0

Purified THC:CBD

i.p

Low

10

10

Purified THC:CBD

i.p

Medium

50

10

Purified THC:CBD

i.p

High

100

10

Crude Extract

Oral Gavage

Control

0

0

Crude Extract

Oral Gavage

Low

10

0.240

Crude Extract

Oral Gavage

Medium

20

0.480

Crude Extract

Oral Gavage

High

50

1.200

Whole Cannabis

Free feeding

Control

0

0

Whole Cannabis

Free feeding

Low

10

0.240

Whole Cannabis

Free feeding

Medium

20

0.480

Whole Cannabis

Free feeding

High

50

1.200

  1. Mice received one of the following treatments (Matrix and Delivery): Purified CBD and THC via i.p., crude extract by oral gavage, or whole Cannabis mixed with nutritional gel by free feeding. The amount of CBD and THC in whole plant material was determined using mass spectrometry. Final dosing of CBD and THC at control, low, medium, and high concentrations are shown