Fig. 6

Significant changes (p < 0.05) in several eCB-like lipid molecules were detected in brains (left) and plasma (right) of mice following i.p. injection of THC/CBD (n = 5). 2-AG levels trended downward in mice receiving THC/CBD (not shown). THC was dosed at 10 mg/kg/day for 14 days while CBD was given at 10 (1:1, Low), 50 (5:1, Medium), and 100 (10:1, High) mg/kg/day. Mass spectrometry was used to quantitate ethanolamides in brains and plasma of mice at study end. Ethanolamide abbreviations: AEA-Arachidonoyl, DEA = Docosatetraenoyl DHEa = Docosahexaenoyl, LEA = Linoleoyl, OEA = Oleoyl, PEA = Palmitoyl, POEA = Palmitoleoyl, SEA = Stearoyl