Fig. 5

Changes in brain (top) and plasma (bottom) levels of neurochemicals were detected following free feeding of whole Cannabis (n = 5, 6). Mass spectrometry was used to quantitate neurochemicals in brains and plasma of mice at study end. Mice were presented either Nutragel control or whole Cannabis in Nutragel at the following doses of CBD and THC, respectively: 10 and 0.240 mg/kg/day (low), 20 and 0.480 mg/kg/day (medium), or 50 and 1.2 mg/kg/day (high). See also Table 1. Mice consumed the food in under 10 min. DOPAC = 3,4-Dihydroxyphenylacetic acid, NAD + = Nicotinamide adenine dinucleotide, Pyr = Pyridoxyal, Trp = Tryptophan, Tyr = Tyrosine. See Table 1 for dosing. Significance thresholds are shown following ANOVA and uncorrected Fisher’s LSD post hoc analysis (*p < 0.05, **p < 0.01)