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Fig. 3 | Journal of Cannabis Research

Fig. 3

From: Oral Cannabis consumption and intraperitoneal THC:CBD dosing results in changes in brain and plasma neurochemicals and endocannabinoids in mice

Fig. 3

Significant changes in brain (top) and plasma (bottom) levels of neurochemicals were detected following i.p. injection of THC/CBD (n = 3–4). THC was dosed at 10 mg/kg/day for 14 days while CBD was given at 10 (1:1, Low), 50 (5:1, Medium), and 100 (10:1, High) mg/kg/day. Mass spectrometry was used to quantitate neurochemicals in brains and plasma of mice at study end. Trp = Tryptophan, Ser = Serotonin, Xan = Xanthurenic Acid, Ratios are of THC:CBD with THC at 10 mg/kg. Quinolinic acid was only detected in mice receiving i.p. THC/CBD (not shown). Significance thresholds are shown following ANOVA and uncorrected Fisher’s LSD post hoc analysis (*p < 0.05, **p < 0.01, ***p < 0.001)

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Journal of Cannabis Research

ISSN: 2522-5782