Fig. 2
From: DMSO potentiates the suppressive effect of dronabinol on sleep apnea and REM sleep in rats
Sleep apnea (A), spontaneous sleep apnea (B), post-sigh sleep apnea (C) and NREM sleep apnea (D) indices quantified from 6 h recordings of conscious chronically-instrumented rat experiments. Indices were quantified as events/hr. Vehicle (25% DMSO in PBS) or dronabinol (10 mg/kg) was injected IP in combination with vehicle (solid bars) or CB1 receptor (AM 251, 5 mg/kg) or CB2 receptor (AM 630, 5 mg/kg) antagonist, or both. There were no significant main effects. Data (mean ± SEM) were analyzed using linear mixed model analysis with repeated/fixed measures (CB agonist and CB antagonist)