Fig. 3.

Effect of HAL 10 mg/L + CBD on light/dark-stimulation response. The distance traveled in the second light and sixth dark condition decreased in the HAL 10 +CBD 1 (mg/L) group compared with the CNTL (a). In the HAL10 +CBD5 group, the distance traveled in all light and dark conditions did not show a significant difference compared with the CNTL (b). In the HAL 10 mg/L + CBD 10 mg/L group, although the distance traveled in the first light condition increased, all dark conditions showed a significant decrease compared with the CNTL (c). In the HAL 10 mg/L + CBD 1 mg/L group, the response from the second to the fifth dark condition was significantly improved compared to the HAL 10 mg/L group (d). In the HAL 10 mg/L + CBD 5 mg/L group, the response was significantly enhanced in the fifth dark condition as compared with HAL 10 mg/L; however, the response was significantly improved in all dark conditions (e). In the HAL 10 mg/L + CBD 10 mg/L group, the response was enhanced only in the first and the third light conditions as compared with the HAL 10 mg/L group (f). CNTL: Control, HAL10: Haloperidol 10 mg/L, CBD 1, 5, 10: Cannabidiol 1, 5, 10 mg/L, ON: light-on period, OFF: light-off period. Tukey–Kramer test; *p <0.05, **p <0.01. All values are presented as means ± SEMs (n=128)