Fig. 3
A Changes over time of concentrations of Δ9THC (ng/mg) in four brain regions following intranasal instillation. Abbreviations: olfactory bulb (OB), cerebral cortex (CTX), hippocampus (HP), and striatum (STR). B Changes over time of THC-COOH and C Δ9THC-OH. Two-way ANOVA analysis (brain regions vs time) was statistically significant for each set of data Δ9THC, THC-OH, and THC=COOH (p=0.05). Each panel showed that the brain region accounted for the greatest percentage of the total variance in levels of Δ9THC, THC-COOH, and THC-OH. N=8 mice per each cohort euthanized at 2 and 4 h; N=6 for the 8-h cohort. Dunnett’s multiple comparison reveals significant differences comparing levels at 4 and 8 h compared to levels at 2 h (* = p< 0.05)