Fig. 8

Effect of nematode treatment with the polar fraction (PF) of MGC 1013 on endurance after exercise. Nematodes treated with different concentrations of 5, 50, and 100 μg/mL of the PF of MGC 1013 were forced to swim during 120 min. After this the distance travelled within the first 5 min on a solid agar medium was scored. After swimming nematodes travel a shorter distance (green Milli-Q water (MQ) untreated control group) when compared to the non-swimming control group (brown bar). Glucose treatment does not enhance performance. Nematode treatment with the PF of MGC 1013 enhances the travel distance of nematodes after swimming in a dose responsive manner, indicative for enhancing overall fitness or energy levels. Mann-Whitney U tests were used to compare the vehicle control conditions (ethanol) to all other conditions, as well as to compare MQ conditions between exercise and rest. Brown bars denote the rest condition (non-swimming); green bars denote the exercise condition (swimming); *** = false discovery rate (FDR)-corrected p < .001