Table 3 Adverse events from initiation of treatment to 3-month follow-up, by MedDRA System Organ Class (SOC) and Preferred Term (PT)
From: Medical cannabis authorization patterns, safety, and associated effects in older adults
| Â | Â | Product profile | |||
|---|---|---|---|---|---|
SOC PT | Overall n (%) | CBD-dominant n (%) | Balanced n (%) | THC-dominant n (%) | Unknown n (%) |
Nervous system disorders | 10 (30.3) | 3 (18.7) | 5 (38.5) | 1 (33.0) | 1 (100.0) |
 Dizziness | 6 (18.2) | 1 (6.2) | 3 (23.1) | 1 (33.0) | 1 (100.0) |
 Headache | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Disturbance in attention | 2 (6.1) | 1 (6.2) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
 Somnolence | 1 (3.0) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
Gastrointestinal disorders | 11 (33.3) | 6 (37.5) | 4 (30.8) | 1 (33.0) | 0 (0.0) |
 Nausea | 3 (9.1) | 1 (6.2) | 1 (7.7) | 1 (33.0) | 0 (0.0) |
 Dry mouth | 3 (9.1) | 1 (6.2) | 2 (15.4) | 0 (0.0) | 0 (0.0) |
 Diarrhea | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Dyspepsia | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Gastrooesophageal reflux disease | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Mouth ulceration | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Reflux gastritis | 1 (3.0) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
Psychiatric disorders | 5 (15.2) | 2 (12.5) | 2 (15.4) | 1 (33.0) | 0 (0.0) |
 Anxiety | 2 (6.1) | 1 (6.2) | 0 (0.0) | 1 (33.0) | 0 (0.0) |
 Mood change | 1 (3.0) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
 Aggression | 1 (3.0) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
 Insomnia | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Ear and labyrinth disorders | 3 (9.1) | 2 (12.5) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
 Tinnitus | 3 (9.1) | 2 (12.5) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
Respiratory, thoracic, and mediastinal disorders | 2 (6.1) | 2 (12.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Cough | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
 Dyspnea | 1 (3.0) | 1 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Metabolism and nutrition disorders | 1 (3.0) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
 Increased appetite | 1 (3.0) | 0 (0.0) | 1 (7.7) | 0 (0.0) | 0 (0.0) |
 Total | 32 | 15 | 13 | 3 | 1 |