The effects of subacute exposure to a water-soluble cannabinol compound in male mice

Table 7 Behavioral observations in mice dosed with CBNT

Behavior	Treatment group	Treatment day^a	Number of affected mice	Total number of incidences^b
Lethargy	Control (0 mg/kg/d)
	0.04 mg/kg/d CBN	3	2	2
	0.1 mg/kg/d CBN	1–3	3	5
	0.4 mg/kg/d CBN
	1.0 mg/kg/d CBN
	4.0 mg/kg/d CBN	2–4	1	3
Hypersensitivity/agitation when stimulated	Control (0 mg/kg/d)
	0.04 mg/kg/d CBN
	0.1 mg/kg/d CBN	3	1	1
	0.4 mg/kg/d CBN
	1.0 mg/kg/d CBN	1.2	1	2
	4.0 mg/kg/d CBN	1–2	1	2
Transient aggression^c	Control (0 mg/kg/d)	3.6	6	6
	0.04 mg/kg/d CBN
	0.1 mg/kg/d CBN
	0.4 mg/kg/d CBN
	1.0 mg/kg/d CBN	4.5	3	3
	4.0 mg/kg/d CBN
Aggression requiring separation^d	Control (0 mg/kg/d)	4	2	2
	0.04 mg/kg/d CBN
	0.1 mg/kg/d CBN
	0.4 mg/kg/d CBN	3	4	4
	1.0 mg/kg/d CBN	2	2	2
	4.0 mg/kg/d CBN	1.10	2	2

CBN, cannabinol, CBNT CBNight™, d day, kg kilogram, mg milligram, SD standard deviation. ^aTreatment day refers to the days on which the sign was observed. ^bTotal number reflects the fact that some mice had symptoms that resolved and then returned. Each day of each mouse displaying the symptom is counted as 1 incident. ^cTransient aggression was defined as the observation of fighting between 2 mice that resolved with the observer tapping on the cage to distract the mice. ^dSeparation and subsequent housing were employed when mice continued fighting despite distraction efforts or if multiple incidences of fighting occurred during the observation period

ISSN: 2522-5782