Table 2 Factors associated with central obesity in univariable and multivariable analyses (logistic regression, ANRS CO22 Hepather cohort, N = 6348)
Variables | Univariable analysis (N = 6348) | Â | Multivariable analysis (N = 5742) | Â |
|---|---|---|---|---|
OR [95% CI] | P-value | aOR [95% CI] | P-value | |
Sex | ||||
 Male (ref.) | 1 |  | 1 |  |
 Female | 1.76 [1.60–1.95] | < 10−3 | 1.49 [1.31–1.67] | < 10−3 |
Age at baseline (years) | 1.04 [1.03–1.04] | < 10−3 | 1.02 [1.01–1.02] | < 10−3 |
Place of birth |  | < 10−3 |  | < 10−3 |
 France (ref.) | 1 |  | 1 |  |
 Europe + North America + Latin America + Australia | 1.06 [0.88–1.27] | 0.571 | 1.03 [0.83–1.27] | 0.804 |
 North Africa + Middle East | 1.51 [1.26–1.81] | < 10−3 | 1.28 [1.04–1.57] | 0.022 |
 Sub-Saharan Africa + the Caribbean | 2.22 [1.78–2.77] | < 10−3 | 1.90 [1.48–2.44] | < 10−3 |
 Asia | 0.99 [0.75–1.32] | 0.967 | 1.02 [0.74–1.42] | 0.890 |
Coffee consumption |  | < 10−3 |  |  |
 0 cups/day (ref.) | 1 |  |  |  |
 1–2 cups/day | 0.92 [0.81–1.04] | 0.166 |  |  |
 ≥ 3 cups/day | 0.69 [0.60–0.78] | < 10−3 |  |  |
Cannabis use |  | < 10−3 |  | < 10−3 |
 Never (ref.) | 1 |  | 1 |  |
 Former | 0.56 [0.49–0.63] | < 10−3 | 0.75 [0.64–0.88] | < 10−3 |
 Current | 0.32 [0.27–0.37] | < 10−3 | 0.45 [0.37–0.55] | < 10−3 |
Tobacco smoking |  | < 10−3 |  | 0.001 |
 Never (ref.) | 1 |  | 1 |  |
 Former | 0.78 [0.69–0.89] | < 10−3 | 1.08 [0.93–1.26] | 0.327 |
 Current | 0.44 [0.39–0.49] | < 10−3 | 0.81 [0.69–0.95] | 0.009 |
Alcohol consumption |  | < 10−3 |  | 0.002 |
 Abstinent without past unhealthy use (ref.) | 1 |  | 1 |  |
 Moderate use | 0.68 [0.61–0.76] | < 10−3 | 1.04 [0.91–1.18] | 0.583 |
 Unhealthy use (past or current) | 0.77 [0.67–0.89] | < 10−3 | 1.35 [1.13–1.61] | 0.001 |
Living in poverty | ||||
 No (ref.) | 1 |  | 1 |  |
 Yes | 1.19 [1.07–1.33] | 0.002 | 1.18 [1.03–1.35] | 0.019 |
Education level | ||||
 < upper secondary school certificate (ref.) | 1 |  | 1 |  |
 ≥ upper secondary school certificate | 0.67 [0.60–0.74] | < 10−3 | 0.71 [0.63–0.80] | < 10−3 |
Employment status | ||||
 No (ref.) | 1 |  | 1 |  |
 Yes | 0.51 [0.46–0.56] | < 10−3 | 0.78 [0.69–0.89] | < 10−3 |
Advanced liver fibrosisa | ||||
 No (ref.) | 1 |  | 1 |  |
 Yes | 1.51 [1.34–1.70] | < 10−3 | 1.15 [1.00–1.31] | 0.044 |
Time since HCV diagnosis (years) | 1.00 [0.99–1.00] | 0.250 |  |  |
HCV treatment history |  | < 10−3 |  | 0.001 |
 None (ref) | 1 |  | 1 |  |
 Interferon-based | 1.31 [1.18–1.46] | < 10−3 | 1.15 [1.02–1.30] | 0.026 |
 1st or 2nd generation DAA | 1.61 [1.35–1.92] | < 10−3 | 1.49 [1.23–1.82] | < 10−3 |
 Other | 1.17 [0.86–1.61] | 0.319 | 0.98 [0.68–1.42] | 0.931 |