Table 4 CBD and THC interactions with enzymes associated with warfarin metabolism (Health Canada 2018; Yamaori et al. 2012; Anderson and Chan 2016; Sachse-Seeboth et al. 2009)
From: Case report: Medical cannabis—warfarin drug-drug interaction
CYP enzyme | CYP Enzyme's Role in Warfarin Metabolism | CBD and CYP Metabolism | THC and CYP Metabolism |
|---|---|---|---|
3A4 | • Metabolizes R-enantiomer | • Substrate • Inhibitor | • Substrate • Inhibitor |
2C9 | • Metabolizes S-enantiomer | • Potential substrate • Inhibitor | • Substrate • Inhibitor |
2C19 | • Metabolizes R-enantiomer | • Substrate • Inhibitor | • Substrate • Inhibitor |
1A1/1A2 | • Metabolizes R-enantiomer | • Potential substrate • Inhibitor | • Not a substrate • Inhibitor |