Table 1 Warfarin dosing, INR, and medical cannabis history
From: Case report: Medical cannabis—warfarin drug-drug interaction
Date of anticoagulation clinic encounter | Warfarin dose (mg per week) | INR | Medical cannabis use | Other comments |
|---|---|---|---|---|
October 15, 2018 | 2.5 mg daily except 5 mg Sundays and Wednesdays (22.5 mg/week) | 2.3 | None | Pt had been stable on this dose of warfarin since May 2016 |
November 8, 2018 | 22.5 mg/week | 3.6-POC 3.28-Lab confirmation | None | Unclear cause for supratherapeutic INR Warfarin dose lowered to 20 mg/week |
November 20, 2018 | 2.5 mg daily except 5 mg on Wednesdays (20 mg/week) | 2.5 | Started daily THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed, November 16, 2018 | No additional comments |
December 6, 2018 | 20 mg/week | 1.6 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | Warfarin dose increased back to 22.5 mg/week |
December 19, 2018 | 2.5 mg daily except 5 mg on Wednesdays and Fridays (22.5 mg/week) | 2.2 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
January 9, 2019 | 22.5 mg/week | 2.3 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
February 6, 2019 | 22.5 mg/week | 2.2 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
March 7, 2019 | 22.5 mg/week | 2.0 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
April 4, 2019 | 22.5 mg/week | 1.9 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
April 18, 2019 | 22.5 mg/week | 2.2 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
May 30, 2019 | 22.5 mg/week | 2.2 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
July 11, 2019 | 22.5 mg/week | 2.2 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
August 22, 2019 | 22.5 mg/week | 1.7 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | No additional comments |
September 5, 2019 | 22.5 mg/week | 2.1 | THC 0.3 mg/CBD 5.3 mg daily and THC 0.625 mg/CBD 0.625 mg daily as needed | Warfarin discontinued and regimen changed to apixaban |