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Table 1 Up-regulated genes of interest (GOIs) after exposure of HSAEpC to various dilutions of cannabis oil extract for 24 h

From: Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)

Symbol

Description

1:400 Dil.

1:800 Dil.

1:1600 Dil.

Fold Change

95% CI

P-value

Fold Change

95% CI

P-value

Fold Change

95% CI

P-value

BCL6

B-cell leukemia/lymphoma 6

2.408

(1.94, 2.88)

0.00006

      

CCL22

Chemokine (C-C motif) ligand 22

5.309

(2.69, 7.93)

0.00045

5.249

(2.83, 7.67)

0.00022

   

CCL24

Chemokine (C-C motif) ligand 24

59.800

(42.54, 77.06)

< 0.00001

      

CCL26

Chemokine (C-C motif) ligand 26

5.396

(3.50, 7.29)

< 0.00001

      

CSF2

Colony stimulating factor 2 (granulocyte-macrophage)

148.914

(118.08, 179.74)

< 0.00001

47.615

(39.28, 55.95)

< 0.00001

4.018

(3.33, 4.70)

< 0.00001

IL4

Interleukin 4

8.696

(6.26, 11.13)

0.00001

12.324

(9.57, 15.08)

< 0.00001

3.679

(2.41, 4.95)

0.00038

IL12A

Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

6.789

(2.15, 11.43)

0.00048

      

IL12B

Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

5.196

(0.00001, 10.54)

0.03230

      

IL13RA2

Interleukin 13 receptor, alpha 2

19.244

(16.80, 21.69)

< 0.00001

23.779

(21.19, 26.37)

< 0.00001

5.049

(4.19, 5.91)

< 0.00001

IL17A

Interleukin 17A

33.457

(21.68, 45.24)

0.00004

35.543

(25.63, 45.46)

< 0.00001

7.563

(5.64, 9.49)

< 0.00001

IL1RL1

Interleukin 1 receptor-like 1

180.497

(122.94, 238.06)

< 0.00001

161.270

(105.45, 217.09)

< 0.00001

7.296

(4.95, 9.64)

< 0.00001

PPARG

Peroxisome proliferator-activated receptor gamma

5.415

(4.81, 6.02)

< 0.00001

7.367

(6.40, 8.34)

< 0.00001

3.004

(2.63, 3.38)

< 0.00001

PRG2

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

   

2.600

(2.04, 3.16)

0.00004

   

PTGDR2

Prostaglandin D2 receptor 2

3.725

(1.55, 5.90)

0.00374

      

TBX21

T-box 21

28.785

(23.31, 34.26)

< 0.00001

      

TSLP

Thymic stromal lymphopoietin

11.999

(9.61, 14.39)

< 0.00001

2.602

(2.03, 3.18)

0.00002