Fig. 6.

Effect of CBD on light/dark-stimulation response. There were no significant differences from CNTL and CBD 1 mg/L nor 5 mg/L (a, b). The distance traveled in the second, third, fourth, fifth, and sixth dark condition decreased in the CBD 10 mg/L group compared with the CNTL (c). In the CBD1 and CBD5 groups, the distance traveled in all dark conditions showed a significant difference compared with HAL 10 mg/L (d, e). In the CBD 10 mg/L group, although the distance traveled in the first and second light and dark conditions, the third and fourth dark conditions showed a significant difference compared with HAL 10 mg/L (f). CNTL: Control, HAL10: Haloperidol 10 mg/L, CBD 1, 5, 10: Cannabidiol 1, 5, 10 mg/L, ON: light-on period, OFF: light-off period. Tukey–Kramer test; *p <0.05, **p <0.01. All values are presented as means ± SEMs (n=128)