Fig. 2.

The effect of CBD and ROP on activity of zebrafish Parkinsonism model. Addition of 1, 5, 10 mg/L of CBD to 10 mg/L of HAL clearly improved the distance traveled at 5 mg/L of CBD compared to 10 mg/L of HAL. When ROP was added at 1, 5, 10 mg/L to HAL 10 mg/L, the travel distance was clearly improved at ROP 10 mg/L compared with HAL 10 mg/L. In addition, there is no significant difference between the HAL10 + CBD1 (mg/L), HAL10 + CBD5 (mg/L), HAL10 + ROP1 (mg/L), HAL10 + ROP5 (mg/L) and HAL10 + ROP10 (mg/L) compared to the CNTL and DMSO groups. CNTL: Control, DMSO: dimethyl sulfoxide 0.05%, HAL10: Haloperidol 10 mg/L, CBD 1, 5, 10: Cannabidiol 1, 5, 10 mg/L, ROP 1, 5, 10: Ropinirole 1, 5, 10 mg/L. Tukey–Kramer test; CNTL vs **p <0.01, HAL10 vs #p <0.05, HAL10 vs ##p <0.01, ns; not significant. All values are presented as means ± SEMs (n=144)