Fig. 1.

HAL-induced Parkinsonism zebrafish model. Comparison between the CNTL and HAL-treated groups at different doses (0.5, 1, 5, 10 mg/L). HAL at 10 mg/L exerted the strongest significant decrease in movement compared with the CNTL (a). The light (ON) /dark (OFF) -stimulation response of the HAL 10 mg/L-treated group was significantly reduced during all dark conditions (first to sixth) compared to that of the CNTL (b). CNTL: Control, DMSO: dimethyl sulfoxide 0.05%, HAL10: Haloperidol 10 mg/L, ON: light-on period, OFF: light-off period. Tukey-Kramer test; *p < 0.05, **p <0.01. All values are presented as means ± standard errors of the mean (SEMs) of at least three independent experiments (n=96)