Fig. 5
Percent of administered dose that accumulates in the brain tissues over time. Ratio (expressed as %) of mean OB concentrations to administered dose is shown in yellow circles. Percent of dose accumulated in all 4 brain regions was determined by calculating the ratio of the mean of 4 brain region concentrations of Δ9THC + metabolites to the administered dose of Δ9THC (268 μg/g). Two-way ANOVA revealed that brain regions contributed 26.9% of total variation (*p<0.005) and time contributed only 9.5% of total variation (NS). OB, olfactory bulb; CTX, cerebral cortex; HI, hippocampus; STR, striatum