C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties

Table 1 Summary of the biological effects of polar fractions (PFs) of cannabis in C. elegans

Variety	*Appetite control*	*Motility*	*Nervous system* *(adverse acute stimulus)*	*Nervous system* *(adverse memory)*
MGC 1003	–	↓	↓	n.d.
MGC 1007	–	–	↓	n.d.
MGC 1009	–	↓	↓	n.d.
MGC 1010	–	–	–	n.d.
MGC 1013	↓	↑	↓	↓
MGC 1027	–	–	↓	n.d.
MGC 1046	–	–	↓	n.d.
MGC 1074	–	–	↓	–
MGC 1101	↑	↓	↓	n.d.
MGC 1104	–	–	–	n.d.
MGC 1106	–	–	–	n.d.
MGC 1122	–	–	↓	–

PFs of different cannabis varieties were used to test the effect on appetite control, body oscillation, motility, and nervous system function in C. elegans. (↓) significant decreased effect; (↑) significant increased effect; (–): no significant effect; n.d. not determined