From: The effects of subacute exposure to a water-soluble cannabinol compound in male mice
Clinical sign | Treatment group | Treatment daya | Number of affected mice | Total number of incidencesb |
---|---|---|---|---|
Rough coat | Control (0 mg/kg/d) | 9 | 1 | 1 |
0.04 mg/kg/d CBN | 4, 7, 8 | 5 | 5 | |
0.1 mg/kg/d CBN | Â | Â | Â | |
0.4 mg/kg/d CBN | 1, 2, 5–7, 13, 14 | 4 | 9 | |
1.0 mg/kg/d CBN | 2, 4, 6, 7 | 8 | 9 | |
4.0 mg/kg/d CBN | 9, 14 | 2 | 2 | |
Ataxia | Control (0 mg/kg/d) | Â | Â | Â |
0.04 mg/kg/d CBN | Â | Â | Â | |
0.1 mg/kg/d CBN | Â | Â | Â | |
0.4 mg/kg/d CBN | 6, 7 | 1 | 2 | |
1.0 mg/kg/d CBN | Â | Â | Â | |
4.0 mg/kg/d CBN | Â | Â | Â | |
Rheum/eye irritation | Control (0 mg/kg/d) | Â | Â | Â |
0.04 mg/kg/d CBN | Â | Â | Â | |
0.1 mg/kg/d CBN | Â | Â | Â | |
0.4 mg/kg/d CBN | 6, 7 | 1 | 2 | |
1.0 mg/kg/d CBN | 1, 2 | 1 | 2 | |
4.0 mg/kg/d CBN | Â | Â | Â | |
Moribund sacrificed | Control (0 mg/kg/d) | Â | Â | Â |
0.04 mg/kg/d CBN | Â | Â | Â | |
0.1 mg/kg/d CBN | Â | Â | Â | |
0.4 mg/kg/d CBN | Â | Â | Â | |
1.0 mg/kg/d CBN | Â | Â | Â | |
4.0 mg/kg/d CBN | 5 | 1 | 1 | |
Found dead in age | Control (0 mg/kg/d) | Â | Â | Â |
0.04 mg/kg/d CBN | 13* | 1 | 1 | |
0.1 mg/kg/d CBN | 4 | 1 | 1 | |
0.4 mg/kg/d CBN | Â | Â | Â | |
1.0 mg/kg/d CBN | Â | Â | Â | |
4.0 mg/kg/d CBN | Â | Â | Â |