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Table 1 Incidence of adverse clinical signs in mice dosed with CBNT

From: The effects of subacute exposure to a water-soluble cannabinol compound in male mice

Clinical sign

Treatment group

Treatment daya

Number of affected mice

Total number of incidencesb

Rough coat

Control (0 mg/kg/d)

9

1

1

0.04 mg/kg/d CBN

4, 7, 8

5

5

0.1 mg/kg/d CBN

   

0.4 mg/kg/d CBN

1, 2, 5–7, 13, 14

4

9

1.0 mg/kg/d CBN

2, 4, 6, 7

8

9

4.0 mg/kg/d CBN

9, 14

2

2

Ataxia

Control (0 mg/kg/d)

   

0.04 mg/kg/d CBN

   

0.1 mg/kg/d CBN

   

0.4 mg/kg/d CBN

6, 7

1

2

1.0 mg/kg/d CBN

   

4.0 mg/kg/d CBN

   

Rheum/eye irritation

Control (0 mg/kg/d)

   

0.04 mg/kg/d CBN

   

0.1 mg/kg/d CBN

   

0.4 mg/kg/d CBN

6, 7

1

2

1.0 mg/kg/d CBN

1, 2

1

2

4.0 mg/kg/d CBN

   

Moribund sacrificed

Control (0 mg/kg/d)

   

0.04 mg/kg/d CBN

   

0.1 mg/kg/d CBN

   

0.4 mg/kg/d CBN

   

1.0 mg/kg/d CBN

   

4.0 mg/kg/d CBN

5

1

1

Found dead in age

Control (0 mg/kg/d)

   

0.04 mg/kg/d CBN

13*

1

1

0.1 mg/kg/d CBN

4

1

1

0.4 mg/kg/d CBN

   

1.0 mg/kg/d CBN

   

4.0 mg/kg/d CBN

   
  1. *Showed signs of rough coat 2 days prior to death. Not included in rough coat numbers since the mouse was later found dead. aTreatment day refers to the days on which the sign was observed. bTotal number reflects the fact that some mice had symptoms that resolved and then returned. Each day of each mouse displaying the symptom is counted as 1 incident. CBN, cannabinol; CBNT, CBNightâ„¢; d, day; kg, kilogram; mg, milligram