Group number | ND | HF-C | HF-C CBD | HF-C THC | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | Fed 6 weeks of normal diet | Fed 6 weeks of high-fat lard diet with 1% cholesterol and 0.5% cholic acid | Fed 6 weeks of high-fat lard diet with 1% cholesterol and 0.5% cholic acid and CBD | Fed 6 weeks of high-fat lard diet with 1% cholesterol and 0.5% cholic acid and THC | |||||||||||||||||
Animal number | 1 | 2 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | 5 | 8 | 1 | 2 | 3 | 4 | 5 |
Organ | Liver | Liver | Liver | Liver | |||||||||||||||||
Hepatocytic vacuolation, consistent with fatty change — centrilobular | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
Inflammatory cell infiltration, multifocal | 0 | 0 | 0 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
Hepatocellular necrosis, focal | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Bile duct hyperplasia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |