Fig. 3
The effect of NP on sodium channel recovery from fast inactivation. Recovery of channel availability from fast inactivation as a function of time, evoked by the indicated voltage protocol (inset), in the presence of DMSO vehicle (
) or NP (3 μg NP/mL) for NaV1.1 (
; n=10), NaV1.2 (
; n=8), NaV1.3 (
; n=10), NaV1.4 (
; n=6), NaV1.5 (
; n=10), NaV1.6 (
; n=11), NaV1.7 (
; n=7) and NaV1.8 (
; n=7). A hyperbola was fitted to pooled averages. Insets show the mean rc values in the presence of DMSO vehicle (black bars) or NP (coloured bars as described above). Data points are mean±SEM. Statistical significance is marked as *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001