Fig. 2From: A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel functionThe effects of NP on activation and steady-state fast inactivation (SSFI). a Voltage-dependence of normalized peak conductance (G/Gmax) and SSFI (I/Imax), evoked by the indicated voltage protocols (insets), in the presence of vehicle ( ) or NP (3 μg NP/mL) for NaV1.1 ( ; n=10; mean diff slope act 1.5±0.3, p=0.002), NaV1.2 ( ; n=8), NaV1.3 ( ; n=10), NaV1.4 ( ; n=6; mean diff slope act 1.6±0.6, p=0.04; mean diff slope inact 0.8±0.3, p=0.03), NaV1.5 ( ; n=10; mean diff slope act 2.1±0.5, p=0.003; mean diff slope inact 0.8±0.3, p=0.003), NaV1.6 ( ; n=11; mean diff slope act 1.3±0.4, p=0.01), NaV1.7 ( ; n=7) and NaV1.8 ( ; n=7). Boltzmann curves were fitted to pooled averages of peak conductance. b Average change in the voltage of half (V0.5) activation and c SSFI initiated by NP (3 μg NP/mL) for NaV1.1 ( ; n=10), NaV1.2 ( ; n=8), NaV1.3 ( ; n=10), NaV1.4 ( ; n=6), NaV1.5 ( ; n=10), NaV1.6 ( ; n=11), NaV1.7 ( ; n=7) and NaV1.8 ( ; n=7). d Average change in the voltage of half V0.5 activation and e SSFI caused by hemp seed oil (3 μg hemp seed oil/mL) for NaV1.1 ( ; n=11), NaV1.2 ( ; n=5), NaV1.3 ( ; n=5), NaV1.4 ( ; n=9), NaV1.5 ( ; n=6), NaV1.6 ( ; n=6), NaV1.7 ( ; n=10) and NaV1.8 ( ; n=5). Data points are mean±SEM. Statistical significance is marked as *p<0.05; **p<0.01; ***p<0.001Back to article page