Fig. 1
NP inhibits peak current amplitude of NaV channels. a Representative current traces, evoked by the indicated voltage protocol (inset), in the presence of DMSO vehicle (
) or NP (3 μg NP/mL) for NaV1.1 (
), NaV1.2 (
), NaV1.3 (
), NaV1.4 (
), NaV1.5 (
), NaV1.6 (
), NaV1.7 (
) and NaV1.8 (
) expressed in HEK 293 or CHO cells. Horizontal scale bars (2 ms) apply to all traces. b Mean normalized peak current amplitude (I/Imax) in the presence of DMSO vehicle (
) or NP (3 μg NP/mL) for NaV1.1 (
; n=10), NaV1.2 (
; n=8), NaV1.3 (
; n=10), NaV1.4 (
; n=6), NaV1.5 (
; n=10), NaV1.6 (
; n=11), NaV1.7 (
; n=7), NaV1.8 (
; n=7) and DMSO vehicle (
 or, hemp seed oil (3 μg hemp seed oil/mL) for NaV1.1 (
; n=9), NaV1.2 (
; n=5), NaV1.3 (
; n=5), NaV1.4 (
; n=9), NaV1.5 (
; n=5), NaV1.6 (
; n=5), NaV1.7 (
; n=11) and NaV1.8 (
; n=7). Data points are mean±SEM. Peak current amplitudes in the presence of NP were compared to DMSO vehicle (
) currents. Peak current amplitudes in the presence of hemp seed oil were compared to DMSO vehicle (
) currents. Statistical significance is marked as *p<0.05; **p<0.01