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Table 1 Pharmacokinetic parameters in mouse plasma and brain

From: Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

  CBGA methyl ester Olivetolic acid
(10 mg/kg, i.p.) (10 mg/kg, i.p.)
Plasma Brain Plasma Brain
Cmax (μg/mL) 1.3 ± 0.3 0.21 ± 0.03* 65 ± 4 0.45 ± 0.06*
tmax (min) 45 30 15 15
t1/2 (min) 81 62 10 14
AUC (μg•min/mL) 171 22 1105 13
Brain-plasma ratio 0.13 0.01
  1. *Converted from measured concentrations (ng/mg brain) assuming density of 1 g/mL