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Table 1 Pharmacokinetic parameters in mouse plasma and brain

From: Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

 

CBGA methyl ester

Olivetolic acid

(10 mg/kg, i.p.)

(10 mg/kg, i.p.)

Plasma

Brain

Plasma

Brain

Cmax (μg/mL)

1.3 ± 0.3

0.21 ± 0.03*

65 ± 4

0.45 ± 0.06*

tmax (min)

45

30

15

15

t1/2 (min)

81

62

10

14

AUC (μg•min/mL)

171

22

1105

13

Brain-plasma ratio

0.13

0.01

  1. *Converted from measured concentrations (ng/mg brain) assuming density of 1 g/mL