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Table 2 Impact of stressors on optimized CDCBD nanoemulsion parameters

From: Synthesis, characterization and stress-testing of a robust quillaja saponin stabilized oil-in-water phytocannabinoid nanoemulsion

System Stressor dz,f (nm) %Δdz ζf (mV) %Δζf [CBD] (mg.g −1)
1a none 125.5 N/A -32.2 N/A 10.8
2 heat 136.8 9 -30.9 -4 10.4
3 freeze-thaw 142.5 13.5 -30.2 -6.2 10.6
4 dilutionb 123.6 -1.5 -25.6 -19.7 N/Ac
5 dilution/carbonationd 135.8 -3.5 -25.0 -8.9 N/Ac
6 6 weeks storage 130.0 3.6 -29.4 -8.7 9.1
  1. aOptimized nanoemulsion, as synthesized
  2. b1 mL nanoemulsion added to HPLC water to obtain a final volume of 355 mL
  3. c[CBD] not measured as dilution is not expected to change it
  4. d1 mL nanoemulsion added to carbonated water to obtain a final volume of 355 mL