Synthesis, characterization and stress-testing of a robust quillaja saponin stabilized oil-in-water phytocannabinoid nanoemulsion

Table 2 Impact of stressors on optimized CD_CBD nanoemulsion parameters

System	Stressor	d_z,f (nm)	%Δd_z	ζ_f (mV)	%Δζ_f	[CBD] (mg.g ⁻¹)
1^a	none	125.5	N/A	-32.2	N/A	10.8
2	heat	136.8	9	-30.9	-4	10.4
3	freeze-thaw	142.5	13.5	-30.2	-6.2	10.6
4	dilution^b	123.6	-1.5	-25.6	-19.7	N/A^c
5	dilution/carbonation^d	135.8	-3.5	-25.0	-8.9	N/A^c
6	6 weeks storage	130.0	3.6	-29.4	-8.7	9.1

^aOptimized nanoemulsion, as synthesized
^b1 mL nanoemulsion added to HPLC water to obtain a final volume of 355 mL
^c[CBD] not measured as dilution is not expected to change it
^d1 mL nanoemulsion added to carbonated water to obtain a final volume of 355 mL

ISSN: 2522-5782