Fig. 2From: Cannabidiol oxidation product HU-331 is a potential anticancer cannabinoid-quinone: a narrative reviewHU-331 inhibits the catalytic cycle of topoisomerase II. TOP2 (orange, red, and blue) binds to two segments of DNA (pink and green). HU-331 blocks ATP hydrolysis by the ATPase domain (orange), which results in the inability to perform strand passage and traps the enzyme on DNABack to article page