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Table 1 An overview to the key properties of common GC-MS method for analysing cannabinoids with a capillary column in six different studies

From: Methods for quantification of cannabinoids: a narrative review

Key capillary column properties Cannabinoids analysed Oven process Carrier gas Range LOD LOQ References
Silica capillary column coated with DB1 16 major cannabinoids Initial 10 °C, 108 °C /min, up to 280 °C Hold for 30 min Helium N/A N/A N/A (Hazekamp et al. 2005)
VA5MS capillary column coated with DB1 Δ9-THC, CBD, CBN, CBG, THCA, CBGA, CBDA Initial 100 °C, 108 °C /min, up to 280 °C Hold for 30 min Helium N/A N/A N/A (Hazekamp et al. 2009)
5% Cross-linked phenylmethyl siloxane capillary column CBG, CBD, CBDA, CBN, CBGA, THC, CBC, THCA Initial 50 °C, 6 °C /min, up to 300 °C, hold for 4 min. (3 min solvent delay was applied) Helium m/za 40–500 N/A N/A (Namdar et al. 2018)
5% Diphenyl/95% dimethyl polysiloxane capillary column THC-THCA Initial 70 °C, 40 °C /min up to 180 °C, then 10 °C/min up to 300 °C
Hold for 6.25 min
Helium 0.10–4.00% (w/w) 0.03% (w/w) 10% (w/w) (Casiraghi et al. 2018)
Cross-linked poly-5% diphenyl-95% dimethyl polysiloxane capillary column CBDA-CBD Initial 45 °C, 2 °C /min, up tp100°C, then 5 °C /min up to 250 °C
Hold for 5 min
Helium m/z 40–500 N/A N/A (Pellati et al. 2018)
5% Cross-linked phenylmethyl siloxane capillary column CBG, CBD, THC, CBC, CBN Initial 50 °C, 6 °C/min, up to 300 °C
Hold for 4 min, (3 min solvent delay was applied)
Helium m/z 40–400 N/A N/A (Namdar et al. 2019)
  1. aM stand for mass and z is charge number of ions. For GC-MS Z is always almost 1, so M/Z is mass