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Table 6 Multivariate analysis results of differences in primary condition reported by 56,860 patients seeking medical cannabis certification by gender and age, with and without interaction

From: Medical cannabis use in the United States: a retrospective database study

Primary Condition Model without interaction between age and gender Model with interaction between age and gender
Coefficient (95% CI) p-value Coefficient (95% CI) p-value
Unspecified Chronic Pain
 Intercept − 0.500 (− 0.557, − 0.443) < 0.001 − 0.647 (− 0.731, − 0.563) < 0.001
 Age 0.000 (− 0.001, 0.001) 0.700 0.003 (0.001, 0.005) 0.001
 Gender (Male) 0.190 (0.156, 0.224) < 0.001 0.430 (0.323, 0.536) < 0.001
 Interaction NA NA − 0.005 (− 0.007, − 0.003) < 0.001
Anxiety
 Intercept − 1.047 (− 1.128, − 0.966) < 0.001 − 0.972 (− 1.085, − 0.859) < 0.001
 Age −0.017 (− 0.019, − 0.015) < 0.001 −0.019 (− 0.021, − 0.016) < 0.001
 Gender (Male) −0.236 (− 0.286, − 0.185) < 0.001 −0.369 (− 0.519, − 0.220) < 0.001
 Interaction NA NA 0.003 (0.000, 0.006) 0.064
Post Traumatic Stress Disorder
 Intercept −1.345 (− 1.442, − 1.249) < 0.001 −0.873 (− 1.011, − 0.737) < 0.001
 Age − 0.023 (− 0.025, − 0.021) < 0.001 −0.034 (− 0.038, − 0.031) < 0.001
 Gender (Male) −0.054 (− 0.114, 0.006) 0.079 −0.846 (− 1.024, − 0.669) < 0.001
 Interaction NA NA 0.019 (0.015, 0.023) < 0.001
Back & Neck Problems
 Intercept −3.718 (− 3.841, − 3.596) < 0.001 −3.772 (− 3.977, − 3.571) < 0.001
 Age 0.015 (0.013, 0.017) < 0.001 0.016 (0.012, 0.020) < 0.001
 Gender (Male) 0.495 (0.423, 0.568) < 0.001 0.572 (0.333, 0.814) < 0.001
 Interaction NA NA −0.002 (− 0.006, 0.003) 0.508
Arthritis
 Intercept −6.013 (− 6.201, − 5.828) < 0.001 −6.081 (− 6.355, − 5.813) < 0.001
 Age 0.056 (0.053, 0.059) < 0.001 0.057 (0.052, 0.061) < 0.001
 Gender (Male) −0.179 (− 0.266, − 0.092) < 0.001 −0.057 (− 0.417, 0.304) 0.755
 Interaction NA NA −0.002 (− 0.008, 0.004) 0.493
Insomnia
 Intercept −3.980 (− 4.143, − 3.818) < 0.001 − 4.620 (− 4.892, − 4.355) < 0.001
 Age 0.010 (0.007, 0.013) < 0.001 0.022 (0.017, 0.027) < 0.001
 Gender (Male) 0.226 (0.130, 0.323) < 0.001 1.190 (0.871, 1.513) < 0.001
 Interaction NA NA −0.020 (− 0.026, − 0.013) < 0.001
Cancer Related Pain
 Intercept −6.200 (− 6.421, − 5.983) < 0.001 − 5.679 (− 5.978, − 5.388) < 0.001
 Age 0.052 (0.049, 0.056) < 0.001 0.043 (0.038, 0.048) < 0.001
 Gender (Male) −0.192 (− 0.296, − 0.088) < 0.001 − 1.184 (− 1.604, − 0.764) < 0.001
 Interaction NA NA 0.017 (0.010, 0.024) < 0.001
Depression
 Intercept −3.026 (− 3.225, − 2.830) < 0.001 −3.007 (− 3.282, − 2.738) < 0.001
 Age −0.019 (− 0.023, − 0.015) < 0.001 −0.019 (− 0.026, − 0.013) < 0.001
 Gender (Male) −0.218 (− 0.341, − 0.094) 0.001 −0.253 (− 0.616, 0.111) 0.173
 Interaction NA NA 0.001 (−0.007, 0.009 0.842
Migraines
 Intercept −2.621 (− 2.805, − 2.438) < 0.001 − 2.689 (− 2.923, − 2.459) < 0.001
 Age −0.021 (− 0.024, − 0.017) < 0.001 −0.019 (− 0.024, − 0.014) < 0.001
 Gender (Male) −0.708 (− 0.827, − 0.590) < 0.001 −0.549 (− 0.896, − 0.202) 0.002
 Interaction NA NA −0.004 (− 0.012, 0.004) 0.339
Muscle Spasms
 Intercept −4.027 (− 4.240, − 3.817) < 0.001 −4.320 (− 4.649, − 4.000) < 0.001
 Age − 0.001 (− 0.005, 0.003) 0.542 0.005 (− 0.001, 0.011) 0.131
 Gender (Male) 0.113 (− 0.015, 0.242) 0.085 0.577 (0.178, 0.981) 0.005
 Interaction NA NA −0.010 (− 0.018, − 0.002) 0.016
ADD/ADHD
 Intercept − 3.030 (− 3.262, − 2.800) < 0.001 − 3.607 (− 3.991, − 3.231) < 0.001
 Age −0.036 (− 0.041, − 0.031) < 0.001 −0.022 (− 0.031, − 0.014) < 0.001
 Gender (Male) 0.535 (0.385, 0.688) < 0.001 1.359 (0.915, 1.809) < 0.001
 Interaction NA NA −0.021 (− 0.032, − 0.011) < 0.001
Chronic Nausea
 Intercept −2.193 (− 2.404, − 1.983) < 0.001 −2.076 (− 2.359, − 1.795) < 0.001
 Age − 0.043 (− 0.048, − 0.038) < 0.001 −0.046 (− 0.053, − 0.039) < 0.001
 Gender (Male) − 0.341 (− 0.473, − 0.207) < 0.001 − 0.567 (− 0.955, − 0.178) 0.004
 Interaction NA NA 0.006 (− 0.004, 0.016) 0.224
Fibromyalgia
 Intercept −4.434 (− 4.699, − 4.176) < 0.001 −4.392 (− 4.671, − 4.121) < 0.001
 Age 0.016 (0.011, 0.021) < 0.001 0.016 (0.010, 0.021) < 0.001
 Gender (Male) − 2.502 (− 2.758, − 2.261) < 0.001 − 2.868 (− 3.715, − 2.069) < 0.001
 Interaction NA NA 0.007 (−0.008, 0.023) 0.352
Headaches
 Intercept −3.439 (− 3.686, − 3.195) < 0.001 −3.632 (− 3.974, − 3.298) < 0.001
 Age − 0.020 (− 0.025, − 0.014) < 0.001 −0.015 (− 0.022, − 0.008) < 0.001
 Gender (Male) −0.272 (− 0.426, − 0.118) 0.001 0.091 (− 0.363, 0.548) 0.695
 Interaction NA NA −0.009 (− 0.019, 0.002) 0.096
Epilepsy
 Intercept −3.622 (− 3.889, − 3.359) < 0.001 −3.720 (− 4.115, − 3.334) < 0.001
 Age −0.023 (− 0.028, − 0.017) < 0.001 −0.020 (− 0.029, − 0.012) < 0.001
 Gender (Male) 0.084 (− 0.082, 0.253) 0.323 0.242 (− 0.247, 0.736) 0.334
 Interaction NA NA −0.004 (− 0.015, 0.007) 0.502
  1. Table 6 shows the results of logistic regression analysis for age and gender as predictors for primary conditions for 56,860 patients. Logistic regression was conducted for each primary condition compared to all other conditions to determine whether age and gender predict reporting the primary condition versus not reporting the primary condition. The coefficient column represents the magnitude of effect and direction of the predictor variable; a negative coefficient for age suggests that younger patients are more likely to report the primary condition, and a negative coefficient for gender suggests that females are more likely to report the primary condition. CI = confidence interval