Table 6 Multivariate analysis results of differences in primary condition reported by 56,860 patients seeking medical cannabis certification by gender and age, with and without interaction
From: Medical cannabis use in the United States: a retrospective database study
Primary Condition | Model without interaction between age and gender | Model with interaction between age and gender | ||
|---|---|---|---|---|
Coefficient (95% CI) | p-value | Coefficient (95% CI) | p-value | |
Unspecified Chronic Pain | ||||
 Intercept | − 0.500 (− 0.557, − 0.443) | < 0.001 | − 0.647 (− 0.731, − 0.563) | < 0.001 |
 Age | 0.000 (− 0.001, 0.001) | 0.700 | 0.003 (0.001, 0.005) | 0.001 |
 Gender (Male) | 0.190 (0.156, 0.224) | < 0.001 | 0.430 (0.323, 0.536) | < 0.001 |
 Interaction | NA | NA | − 0.005 (− 0.007, − 0.003) | < 0.001 |
Anxiety | ||||
 Intercept | − 1.047 (− 1.128, − 0.966) | < 0.001 | − 0.972 (− 1.085, − 0.859) | < 0.001 |
 Age | −0.017 (− 0.019, − 0.015) | < 0.001 | −0.019 (− 0.021, − 0.016) | < 0.001 |
 Gender (Male) | −0.236 (− 0.286, − 0.185) | < 0.001 | −0.369 (− 0.519, − 0.220) | < 0.001 |
 Interaction | NA | NA | 0.003 (0.000, 0.006) | 0.064 |
Post Traumatic Stress Disorder | ||||
 Intercept | −1.345 (− 1.442, − 1.249) | < 0.001 | −0.873 (− 1.011, − 0.737) | < 0.001 |
 Age | − 0.023 (− 0.025, − 0.021) | < 0.001 | −0.034 (− 0.038, − 0.031) | < 0.001 |
 Gender (Male) | −0.054 (− 0.114, 0.006) | 0.079 | −0.846 (− 1.024, − 0.669) | < 0.001 |
 Interaction | NA | NA | 0.019 (0.015, 0.023) | < 0.001 |
Back & Neck Problems | ||||
 Intercept | −3.718 (− 3.841, − 3.596) | < 0.001 | −3.772 (− 3.977, − 3.571) | < 0.001 |
 Age | 0.015 (0.013, 0.017) | < 0.001 | 0.016 (0.012, 0.020) | < 0.001 |
 Gender (Male) | 0.495 (0.423, 0.568) | < 0.001 | 0.572 (0.333, 0.814) | < 0.001 |
 Interaction | NA | NA | −0.002 (− 0.006, 0.003) | 0.508 |
Arthritis | ||||
 Intercept | −6.013 (− 6.201, − 5.828) | < 0.001 | −6.081 (− 6.355, − 5.813) | < 0.001 |
 Age | 0.056 (0.053, 0.059) | < 0.001 | 0.057 (0.052, 0.061) | < 0.001 |
 Gender (Male) | −0.179 (− 0.266, − 0.092) | < 0.001 | −0.057 (− 0.417, 0.304) | 0.755 |
 Interaction | NA | NA | −0.002 (− 0.008, 0.004) | 0.493 |
Insomnia | ||||
 Intercept | −3.980 (− 4.143, − 3.818) | < 0.001 | − 4.620 (− 4.892, − 4.355) | < 0.001 |
 Age | 0.010 (0.007, 0.013) | < 0.001 | 0.022 (0.017, 0.027) | < 0.001 |
 Gender (Male) | 0.226 (0.130, 0.323) | < 0.001 | 1.190 (0.871, 1.513) | < 0.001 |
 Interaction | NA | NA | −0.020 (− 0.026, − 0.013) | < 0.001 |
Cancer Related Pain | ||||
 Intercept | −6.200 (− 6.421, − 5.983) | < 0.001 | − 5.679 (− 5.978, − 5.388) | < 0.001 |
 Age | 0.052 (0.049, 0.056) | < 0.001 | 0.043 (0.038, 0.048) | < 0.001 |
 Gender (Male) | −0.192 (− 0.296, − 0.088) | < 0.001 | − 1.184 (− 1.604, − 0.764) | < 0.001 |
 Interaction | NA | NA | 0.017 (0.010, 0.024) | < 0.001 |
Depression | ||||
 Intercept | −3.026 (− 3.225, − 2.830) | < 0.001 | −3.007 (− 3.282, − 2.738) | < 0.001 |
 Age | −0.019 (− 0.023, − 0.015) | < 0.001 | −0.019 (− 0.026, − 0.013) | < 0.001 |
 Gender (Male) | −0.218 (− 0.341, − 0.094) | 0.001 | −0.253 (− 0.616, 0.111) | 0.173 |
 Interaction | NA | NA | 0.001 (−0.007, 0.009 | 0.842 |
Migraines | ||||
 Intercept | −2.621 (− 2.805, − 2.438) | < 0.001 | − 2.689 (− 2.923, − 2.459) | < 0.001 |
 Age | −0.021 (− 0.024, − 0.017) | < 0.001 | −0.019 (− 0.024, − 0.014) | < 0.001 |
 Gender (Male) | −0.708 (− 0.827, − 0.590) | < 0.001 | −0.549 (− 0.896, − 0.202) | 0.002 |
 Interaction | NA | NA | −0.004 (− 0.012, 0.004) | 0.339 |
Muscle Spasms | ||||
 Intercept | −4.027 (− 4.240, − 3.817) | < 0.001 | −4.320 (− 4.649, − 4.000) | < 0.001 |
 Age | − 0.001 (− 0.005, 0.003) | 0.542 | 0.005 (− 0.001, 0.011) | 0.131 |
 Gender (Male) | 0.113 (− 0.015, 0.242) | 0.085 | 0.577 (0.178, 0.981) | 0.005 |
 Interaction | NA | NA | −0.010 (− 0.018, − 0.002) | 0.016 |
ADD/ADHD | ||||
 Intercept | − 3.030 (− 3.262, − 2.800) | < 0.001 | − 3.607 (− 3.991, − 3.231) | < 0.001 |
 Age | −0.036 (− 0.041, − 0.031) | < 0.001 | −0.022 (− 0.031, − 0.014) | < 0.001 |
 Gender (Male) | 0.535 (0.385, 0.688) | < 0.001 | 1.359 (0.915, 1.809) | < 0.001 |
 Interaction | NA | NA | −0.021 (− 0.032, − 0.011) | < 0.001 |
Chronic Nausea | ||||
 Intercept | −2.193 (− 2.404, − 1.983) | < 0.001 | −2.076 (− 2.359, − 1.795) | < 0.001 |
 Age | − 0.043 (− 0.048, − 0.038) | < 0.001 | −0.046 (− 0.053, − 0.039) | < 0.001 |
 Gender (Male) | − 0.341 (− 0.473, − 0.207) | < 0.001 | − 0.567 (− 0.955, − 0.178) | 0.004 |
 Interaction | NA | NA | 0.006 (− 0.004, 0.016) | 0.224 |
Fibromyalgia | ||||
 Intercept | −4.434 (− 4.699, − 4.176) | < 0.001 | −4.392 (− 4.671, − 4.121) | < 0.001 |
 Age | 0.016 (0.011, 0.021) | < 0.001 | 0.016 (0.010, 0.021) | < 0.001 |
 Gender (Male) | − 2.502 (− 2.758, − 2.261) | < 0.001 | − 2.868 (− 3.715, − 2.069) | < 0.001 |
 Interaction | NA | NA | 0.007 (−0.008, 0.023) | 0.352 |
Headaches | ||||
 Intercept | −3.439 (− 3.686, − 3.195) | < 0.001 | −3.632 (− 3.974, − 3.298) | < 0.001 |
 Age | − 0.020 (− 0.025, − 0.014) | < 0.001 | −0.015 (− 0.022, − 0.008) | < 0.001 |
 Gender (Male) | −0.272 (− 0.426, − 0.118) | 0.001 | 0.091 (− 0.363, 0.548) | 0.695 |
 Interaction | NA | NA | −0.009 (− 0.019, 0.002) | 0.096 |
Epilepsy | ||||
 Intercept | −3.622 (− 3.889, − 3.359) | < 0.001 | −3.720 (− 4.115, − 3.334) | < 0.001 |
 Age | −0.023 (− 0.028, − 0.017) | < 0.001 | −0.020 (− 0.029, − 0.012) | < 0.001 |
 Gender (Male) | 0.084 (− 0.082, 0.253) | 0.323 | 0.242 (− 0.247, 0.736) | 0.334 |
 Interaction | NA | NA | −0.004 (− 0.015, 0.007) | 0.502 |