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Table 3 The EC50 values for each cultivar in each behavioral assay

From: A pharmacological characterization of Cannabis sativa chemovar extracts

Positive Control

Tail Suspension (s)

Hot Plate Latency (s)

alogED50 ± SEM (mg/kg)

bMaximum Effect

celogED50 ± SEM

(mg/kg)

Maximum Effect

Morphine

0.56 ± 0.29

 

0.39 ± 0.12

 

Δ9-THC

−0.14 ± 0.59

100%

0.03 ± 0.13

100%

Cultivar Sample

CTL-H01.H3

−0.37 ± 0.23

151 ± 7%**

−0.31 ± 0.09

69 ± 17%

CTL-H01.H2

− 0.13 ± 0.29

118 ± 12%

0.08 ± 0.16

104 ± 12%

CTL-P01.H1

–

–

0.03 ± 0.13

106 ± 9%

CTL-G01.H8

0.35 ± 1.13

101 ± 17%

0.12 ± 0.10

116 ± 0%4

CTL-G03.H2

0.14 ± 0.67

112 ± 3%

–

–

CTL-X02.H1

−0.48 ± 0.25

146 ± 8%*

−0.37 ± 0.10

111 ± 4%

  1. alogED50 values are presented for i.v. dose administration of positive controls or cultivar samples
  2. bMaximum effect normalized to the maximum effect of Δ9-THC at a dose of 3 mg/kg (with the exception of CTL-X02.H1 compared at 2 mg/kg)
  3. cThe elogED50 is the ethical estimated dose producing a 50% response (see methods for detailed explanation)
  4. dAll animals reached the ethical cutoff threshold
  5. - Indicates that no ED50 value could be determined (see text for details)
  6. * indicates a statistically significant difference (P < 0.05) compared to Δ9-THC, ** indicates a statistically significant difference (P < 0.01) compared to Δ9-THC
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Journal of Cannabis Research

ISSN: 2522-5782