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Table 3 The EC50 values for each cultivar in each behavioral assay

From: A pharmacological characterization of Cannabis sativa chemovar extracts

Positive ControlTail Suspension (s)Hot Plate Latency (s)
alogED50 ± SEM (mg/kg)bMaximum EffectcelogED50 ± SEM
(mg/kg)
Maximum Effect
Morphine0.56 ± 0.29 0.39 ± 0.12 
Δ9-THC−0.14 ± 0.59100%0.03 ± 0.13100%
Cultivar Sample
CTL-H01.H3−0.37 ± 0.23151 ± 7%**−0.31 ± 0.0969 ± 17%
CTL-H01.H2− 0.13 ± 0.29118 ± 12%0.08 ± 0.16104 ± 12%
CTL-P01.H10.03 ± 0.13106 ± 9%
CTL-G01.H80.35 ± 1.13101 ± 17%0.12 ± 0.10116 ± 0%4
CTL-G03.H20.14 ± 0.67112 ± 3%
CTL-X02.H1−0.48 ± 0.25146 ± 8%*−0.37 ± 0.10111 ± 4%
  1. alogED50 values are presented for i.v. dose administration of positive controls or cultivar samples
  2. bMaximum effect normalized to the maximum effect of Δ9-THC at a dose of 3 mg/kg (with the exception of CTL-X02.H1 compared at 2 mg/kg)
  3. cThe elogED50 is the ethical estimated dose producing a 50% response (see methods for detailed explanation)
  4. dAll animals reached the ethical cutoff threshold
  5. - Indicates that no ED50 value could be determined (see text for details)
  6. * indicates a statistically significant difference (P < 0.05) compared to Δ9-THC, ** indicates a statistically significant difference (P < 0.01) compared to Δ9-THC