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Table 3 The EC50 values for each cultivar in each behavioral assay

From: A pharmacological characterization of Cannabis sativa chemovar extracts

Positive Control Tail Suspension (s) Hot Plate Latency (s)
alogED50 ± SEM (mg/kg) bMaximum Effect celogED50 ± SEM
(mg/kg)
Maximum Effect
Morphine 0.56 ± 0.29   0.39 ± 0.12  
Δ9-THC −0.14 ± 0.59 100% 0.03 ± 0.13 100%
Cultivar Sample
CTL-H01.H3 −0.37 ± 0.23 151 ± 7%** −0.31 ± 0.09 69 ± 17%
CTL-H01.H2 − 0.13 ± 0.29 118 ± 12% 0.08 ± 0.16 104 ± 12%
CTL-P01.H1 0.03 ± 0.13 106 ± 9%
CTL-G01.H8 0.35 ± 1.13 101 ± 17% 0.12 ± 0.10 116 ± 0%4
CTL-G03.H2 0.14 ± 0.67 112 ± 3%
CTL-X02.H1 −0.48 ± 0.25 146 ± 8%* −0.37 ± 0.10 111 ± 4%
  1. alogED50 values are presented for i.v. dose administration of positive controls or cultivar samples
  2. bMaximum effect normalized to the maximum effect of Δ9-THC at a dose of 3 mg/kg (with the exception of CTL-X02.H1 compared at 2 mg/kg)
  3. cThe elogED50 is the ethical estimated dose producing a 50% response (see methods for detailed explanation)
  4. dAll animals reached the ethical cutoff threshold
  5. - Indicates that no ED50 value could be determined (see text for details)
  6. * indicates a statistically significant difference (P < 0.05) compared to Δ9-THC, ** indicates a statistically significant difference (P < 0.01) compared to Δ9-THC