Fig. 3

The effects of cannabis cultivar extracts were examined in the tail suspension assay. Mice were intravenously dosed with control (vehicle) or CTL-H01-H3 (0.1, 0.3, 1 and 3 mg/kg) (n = 10 per group, 1 animal excluded from 0.01, 0.3, and 1 mg/kg), CTL-H01-H2 (0.1, 0.3, 1, 3 and 6 mg/kg) (n = 6 per dose with 1 animal excluded from the 0.1 mg/kg group), CTL-P01-H1 (0.1, 0.3, 1, 3 and 6 mg/kg) (n = 6 per group, 2 animals and 1 animal excluded from the 1 mg/kg and 6 mg/kg groups, respectively), CTL-G01-H8 (0.03, 0.1, 0.3, 1 and 3 mg/kg) (n = 6 per group with 1 animal excluded from 0.03, 0.1, 0.3, and 1 mg/kg), CTL-G03-H2 (0.03, 0.1, 0.3, 1 and 3 mg/kg) (n = 6 per group with 1 animal excluded from 1 mg/kg) or CTL-X02-H1 (0.1, 0.3, 1, and 2 mg/kg) (n = 10 per group, 1 animal excluded from 0.01 and 2 mg/kg) cannabis cultivar extract. The curves have been summarized on the same set of axes to facilitate visual comparisons. Immobility time was evaluated 20 min post dose. Data are presented as the mean ± SEM. Data were fit using a 3 parameter log (agonist) vs. response non-linear regression model. Dosing was based on the Δ⁹-THC content of the cannabis cultivar extract, as analyzed by HPLC