| | Group I 10 ± 0.1 mg | Group II 15 ± 0.1 mg | Group III 20 ± 0.1 mg | Group IV 25 ± 0.1 mg |
|---|
Δ9-THC Cmax (ng/mL) | 35.43 ± 5.97 | 51.47 ± 13.79 | 72.37 ± 15.93 | 88.63 ± 14.75 |
AUC0-∞ (ng min/mL) | 441.59 ± 88.49 | 624 ± 123.56 | 698.35 ± 174.98 | 971.36 ± 310.4 |
Tmax (min) | 3.666 ± 0.471 | 3.333 ± 0.471 | 2.666 ± 0.942 | 3 ± 0.816 |
- Each THC dosage group concise of four healthy volunteers. Both Δ9-THC Cmax and AUC0-∞ measured in plasma of the volunteers and calculated from the same data, are showing a linear increase in mean maximum plasma concentration of THC (Cmax) and area under the curve (AUC) both with no change in the time needed to reach such concentration
- THC Cmax Tetrahydrocannabinol maximum concentration, AUC Area under the curve, Tmax time to reach maximum concentration
