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Table 2 Down-regulated GOIs after exposure of HSAEpC to various dilutions of cannabis oil extract for 24 h

From: Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)

Symbol

Description

1:400 Dil.

1:800 Dil.

1:1600 Dil.

Fold Change

95% CI

P-value

Fold Change

95% CI

P-value

Fold Change

95% CI

P-value

ADRB2

Adrenergic receptor, beta 2

0.462

(0.40, 0.53)

0.00001

      

AREG

Amphiregulin

0.476

(0.41, 0.54)

< 0.00001

      

CCL5

Chemokine (C-C motif) ligand 5

0.226

(0.10, 0.36)

0.00119

      

CLCA1

Chloride channel accessory 1

0.129

(0.03, 0.23)

0.02891

0.162

(0.06, 0.26)

0.03048

   

CMA1

Chymase 1, mast cell

0.068

(0.04, 0.10)

0.00037

0.353

(0.20, 0.50)

0.00421

   

EPX

Eosinophil peroxidase

0.037

(0.03, 0.04)

< 0.00001

0.213

(0.11, 0.31)

< 0.00001

   

FOXP3

Forkhead box P3

0.257

(0.12, 0.40)

0.00038

      

IL3RA

Interleukin 3 receptor, alpha (low affinity)

   

0.344

(0.16, 0.52)

0.00364

   

IL4R

Interleukin 4 receptor

0.261

(0.24, 0.28)

< 0.00001

      

IL5

Interleukin 5 (colony-stimulating factor, eosinophil)

0.319

(0.06, 0.58)

0.01014

      

IL13RA1

Interleukin 13 receptor, alpha 1

0.343

(0.29, 0.40)

< 0.00001

      

IL33

Interleukin 33

0.185

(0.16, 0.21)

< 0.00001

      

LTB4R

Leukotriene B4 receptor

0.194

(0.16, 0.23)

< 0.00001

0.451

(0.39, 0.52)

0.00001

   

MAF

V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

0.237

(0.20, 0.28)

< 0.00001

0.330

(0.29, 0.37)

0.00001

   

MMP9

Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase)

0.274

(0.22, 0.33)

0.00001

      

PMCH

Pro-melanin-concentrating hormone

0.271

(0.17, 0.37)

0.00188

0.087

(0.03, 0.14)

0.00047

   

POSTN

Periostin, osteoblast specific factor

0.176

(0.16, 0.19)

< 0.00001

      

RORC

RAR-related orphan receptor C

0.180

(0.00001, 0.36)

0.02731

      

SATB1

SATB homeobox 1

0.481

(0.31, 0.65)

0.00148

      

STAT5A

Signal transducer and activator of transcription 5A

0.328

(0.27, 0.38)

0.00001

      

TNFSF4

Tumor necrosis factor (ligand) superfamily, member 4

0.197

(0.08, 0.31)

< 0.00001