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Table 2 Association of Cannabis use, and Total and Differential WBC Count. Data for the US NHANES, 2005–2016

From: Total and differential white blood cell count in cannabis users: results from the cross-sectional National Health and Nutrition Examination Survey, 2005–2016

Cannabis use status Never Former p- valuec Occasional p- valuec Heavy p- valuec
Total WBC count (cells/uL)
 Crude β (95% CI) 0 (referent) 83 (16, 150) 0.02 140 (−6, 286) 0.06 463 (343, 583) < 0.0001
 Age-sex adjusted β (95% CI)a 0 (referent) 99 (31, 167) 0.005 149 (3, 294) 0.04 477 (359, 595) < 0.0001
 Multivariable adjusted β (95% CI)b 0 (referent) −26 (−94, 43) 0.46 −36 (− 170, 98) 0.59 189 (74, 304) 0.001
Lymphocyte count (cells/uL)
 Crude β (95% CI) 0 (referent) −3 (− 37, 30) 0.79 49 (− 31, 130) 0.11 111 (44, 179) < 0.0001
 Age-sex adjusted β (95% CI)a 0 (referent) 7 (−26, 39) 0.58 36 (−43, 115) 0.23 99 (35, 163) < 0.0001
 Multivariable adjusted β (95% CI)b 0 (referent) −14 (−45, 18) 0.25 −29 (− 106, 48) 0.33 11 (−57, 79) 0.68
Monocyte count (cells/uL)
 Crude β (95% CI) 0 (referent) 15 (7, 24) < 0.0001 33 (14, 53) < 0.0001 55 (36, 73) < 0.0001
 Age-sex adjusted β (95% CI)a 0 (referent) 11 (2, 19) 0.001 23 (3, 43) 0.003 40 (22, 58) < 0.0001
 Multivariable adjusted β (95% CI)b 0 (referent) −1 (−10, 7) 0.66 7 (− 11, 26) 0.30 18 (− 1, 37) 0.01
Neutrophil count (cells/uL)
 Crude β (95% CI) 0 (referent) 62 (−13, 137) 0.03 40 (− 103, 184) 0.46 289 (164, 414) < 0.0001
 Age-sex adjusted β (95% CI)a 0 (referent) 75 (−2, 151) 0.01 76 (−66, 219) 0.16 335 (210, 460) < 0.0001
 Multivariable adjusted β (95% CI)b 0 (referent) −12 (−94, 70) 0.70 − 18 (− 156, 120) 0.74 172 (44, 299) 0.001
Basophil count (cells/uL)
 Crude β (95% CI) 0 (referent) 2 (−1, 5) 0.09 4 (−2, 9) 0.09 6 (− 1, 12) 0.02
 Age-sex adjusted β (95% CI)a 0 (referent) 2 (− 1, 5) 0.11 5 (− 1, 11) 0.03 7 (1, 14) 0.005
 Multivariable adjusted β (95% CI)b 0 (referent) 0 (−3, 3) 0.84 0 (−6, 6) 0.86 1 (− 6, 8) 0.69
Eosinophil count (cells/uL)
 Crude β (95% CI) 0 (referent) 6 (−2, 14) 0.04 16 (1, 31) 0.006 8 (−8, 25) 0.19
 Age-sex adjusted β (95% CI)a 0 (referent) 4 (−4, 12) 0.21 12 (−3, 27) 0.04 2 (− 14, 19) 0.69
 Multivariable adjusted β (95% CI)b 0 (referent) 0 (−9, 8) 0.91 4 (− 12, 21) 0.49 − 8 (− 26, 9) 0.23
  1. a Estimates adjusted for age (years), age squared and sex
  2. b Estimates adjusted for age (years), age squared, sex, race/ethnicity (White, Black, Hispanic, all others), education (<high school, high school, >high school), survey cycle (2005–06, 2007–08, 2009–10, 2011–12, 2013–14, 2015–16), body mass index (Kg/m2), alcohol drinking (non-drinker, occasional, daily) and tobacco cigarette smoking (never, former, occasional, daily)
  3. c 95% confidence intervals are presented in the total WBC count analyses whereas 99% confidence intervals are presented in the differential count analyses to adjust for multiple testing