Total and differential white blood cell count in cannabis users: results from the cross-sectional National Health and Nutrition Examination Survey, 2005–2016

Alshaarawy, Omayma

doi:10.1186/s42238-019-0007-8

Journal of Cannabis Research

Table 2 Association of Cannabis use, and Total and Differential WBC Count. Data for the US NHANES, 2005–2016

From: Total and differential white blood cell count in cannabis users: results from the cross-sectional National Health and Nutrition Examination Survey, 2005–2016

Cannabis use status	Never	Former	p- value^c	Occasional	p- value^c	Heavy	p- value^c
Total WBC count (cells/uL)
Crude β (95% CI)	0 (referent)	83 (16, 150)	0.02	140 (−6, 286)	0.06	463 (343, 583)	< 0.0001
Age-sex adjusted β (95% CI)^a	0 (referent)	99 (31, 167)	0.005	149 (3, 294)	0.04	477 (359, 595)	< 0.0001
Multivariable adjusted β (95% CI)^b	0 (referent)	−26 (−94, 43)	0.46	−36 (− 170, 98)	0.59	189 (74, 304)	0.001
Lymphocyte count (cells/uL)
Crude β (95% CI)	0 (referent)	−3 (− 37, 30)	0.79	49 (− 31, 130)	0.11	111 (44, 179)	< 0.0001
Age-sex adjusted β (95% CI)^a	0 (referent)	7 (−26, 39)	0.58	36 (−43, 115)	0.23	99 (35, 163)	< 0.0001
Multivariable adjusted β (95% CI)^b	0 (referent)	−14 (−45, 18)	0.25	−29 (− 106, 48)	0.33	11 (−57, 79)	0.68
Monocyte count (cells/uL)
Crude β (95% CI)	0 (referent)	15 (7, 24)	< 0.0001	33 (14, 53)	< 0.0001	55 (36, 73)	< 0.0001
Age-sex adjusted β (95% CI)^a	0 (referent)	11 (2, 19)	0.001	23 (3, 43)	0.003	40 (22, 58)	< 0.0001
Multivariable adjusted β (95% CI)^b	0 (referent)	−1 (−10, 7)	0.66	7 (− 11, 26)	0.30	18 (− 1, 37)	0.01
Neutrophil count (cells/uL)
Crude β (95% CI)	0 (referent)	62 (−13, 137)	0.03	40 (− 103, 184)	0.46	289 (164, 414)	< 0.0001
Age-sex adjusted β (95% CI)^a	0 (referent)	75 (−2, 151)	0.01	76 (−66, 219)	0.16	335 (210, 460)	< 0.0001
Multivariable adjusted β (95% CI)^b	0 (referent)	−12 (−94, 70)	0.70	− 18 (− 156, 120)	0.74	172 (44, 299)	0.001
Basophil count (cells/uL)
Crude β (95% CI)	0 (referent)	2 (−1, 5)	0.09	4 (−2, 9)	0.09	6 (− 1, 12)	0.02
Age-sex adjusted β (95% CI)^a	0 (referent)	2 (− 1, 5)	0.11	5 (− 1, 11)	0.03	7 (1, 14)	0.005
Multivariable adjusted β (95% CI)^b	0 (referent)	0 (−3, 3)	0.84	0 (−6, 6)	0.86	1 (− 6, 8)	0.69
Eosinophil count (cells/uL)
Crude β (95% CI)	0 (referent)	6 (−2, 14)	0.04	16 (1, 31)	0.006	8 (−8, 25)	0.19
Age-sex adjusted β (95% CI)^a	0 (referent)	4 (−4, 12)	0.21	12 (−3, 27)	0.04	2 (− 14, 19)	0.69
Multivariable adjusted β (95% CI)^b	0 (referent)	0 (−9, 8)	0.91	4 (− 12, 21)	0.49	− 8 (− 26, 9)	0.23

^a Estimates adjusted for age (years), age squared and sex
^b Estimates adjusted for age (years), age squared, sex, race/ethnicity (White, Black, Hispanic, all others), education (<high school, high school, >high school), survey cycle (2005–06, 2007–08, 2009–10, 2011–12, 2013–14, 2015–16), body mass index (Kg/m²), alcohol drinking (non-drinker, occasional, daily) and tobacco cigarette smoking (never, former, occasional, daily)
^c 95% confidence intervals are presented in the total WBC count analyses whereas 99% confidence intervals are presented in the differential count analyses to adjust for multiple testing

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ISSN: 2522-5782

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